SINGAPORE: Losing weight could now be as easy as swallowing a pill.
Researchers from the Nanyang Technological University (NTU) and National University Health System (NUHS) have invented a pill designed to make one feel full, thus helping with weight management.
AdvertisementOn Wednesday (Apr 24), the researchers demonstrated a prototype of the self-inflating EndoPil, which reduces food intake by filling up space in the stomach.
The capsule can be taken with water, just like regular medication, and will inflate with gas once it reaches the stomach.
The deflated EndoPil capsule and the inflated capsule being compared to a S$1 coin. (Photo: Cindy Co)
“The balloons actually mimic food,” said clinician-innovator at NUHS, Professor Lawrence Ho. “The top part of your stomach controls appetite. Once the balloon occupies the top part of your stomach, you will feel full.”
AdvertisementAdvertisementThe capsule is largely meant for obese patients, in cases where non-surgical weight loss methods such as behavioural procedures and drug therapy have failed.
It is "less invasive" and cheaper than surgery, but produces "close to surgical effects", said Prof Ho.
HOW IT WORKS
In its capsule form, the EndoPil measures 3cm by 1cm and inflates to a volume of 120ml, or roughly the size of a small potato.
NTU Dean of Engineering, Professor Louis Phee, explained that a simple chemical reaction is all it takes to fill the capsule with gas.
“We have a valve connected to a small magnet in a pill. One chamber will hold an acid, one of them is citric acid. If you mix these two chemicals together, you produce carbon dioxide,” he said.
He added that the chemicals would be natural ingredients used in everyday household activities such as lemon juice and baking soda.
An external magnet would be used to activate the chemical reaction.
When used in regular treatment, researchers expect the balloon to remain in the body for about two weeks to a month. Thereafter, the balloon will deflate on its own and pass out of the body naturally.
RISKS
The risks involved in using EndoPilare mostly related to the inflation process, said Prof Ho.
“If it blows up too early, (it will tear the oesophagus). If you blow it up too late, it will stay in the small intestine and cause blockage.
“In the stomach, you have to make sure that it won’t over-inflate or fail to inflate, and that it will deflate at the right time,” he said.
But this is not a problem unique to the EndoPil, said Prof Ho, adding that endoscopy, which is a non-surgical procedure to examine the digestive tract, "has the same problem".
The inflated EndoPil capsule as seen in a demonstration. (Photo: Cindy Co)
NEXT STEPS
The EndoPil is still in its early stages of development.
The team has only tried the product on pigs, as well as one human volunteer.
Trials are expected to continue over the next two years as laid out in the National University of Singapore’s Institutional Review Board guidelines.
Ultimately, the team hopes to focus their efforts on making the product safe for use.
"Our next step is to try and show that people can swallow the capsule without an endoscope," said Prof Ho.
“Over the next two years, it’s all about engineering - to make sure that even if it fails, it will fail safely,” said Prof Phee.
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Researchers from the Nanyang Technological University (NTU) and National University Health System (NUHS) have invented a pill designed to make one feel full, thus helping with weight management.
AdvertisementOn Wednesday (Apr 24), the researchers demonstrated a prototype of the self-inflating EndoPil, which reduces food intake by filling up space in the stomach.
The capsule can be taken with water, just like regular medication, and will inflate with gas once it reaches the stomach.
“The balloons actually mimic food,” said clinician-innovator at NUHS, Professor Lawrence Ho. “The top part of your stomach controls appetite. Once the balloon occupies the top part of your stomach, you will feel full.”
AdvertisementAdvertisementThe capsule is largely meant for obese patients, in cases where non-surgical weight loss methods such as behavioural procedures and drug therapy have failed.
It is "less invasive" and cheaper than surgery, but produces "close to surgical effects", said Prof Ho.
HOW IT WORKS
In its capsule form, the EndoPil measures 3cm by 1cm and inflates to a volume of 120ml, or roughly the size of a small potato.
NTU Dean of Engineering, Professor Louis Phee, explained that a simple chemical reaction is all it takes to fill the capsule with gas.
“We have a valve connected to a small magnet in a pill. One chamber will hold an acid, one of them is citric acid. If you mix these two chemicals together, you produce carbon dioxide,” he said.
He added that the chemicals would be natural ingredients used in everyday household activities such as lemon juice and baking soda.
An external magnet would be used to activate the chemical reaction.
When used in regular treatment, researchers expect the balloon to remain in the body for about two weeks to a month. Thereafter, the balloon will deflate on its own and pass out of the body naturally.
RISKS
The risks involved in using EndoPilare mostly related to the inflation process, said Prof Ho.
“If it blows up too early, (it will tear the oesophagus). If you blow it up too late, it will stay in the small intestine and cause blockage.
“In the stomach, you have to make sure that it won’t over-inflate or fail to inflate, and that it will deflate at the right time,” he said.
But this is not a problem unique to the EndoPil, said Prof Ho, adding that endoscopy, which is a non-surgical procedure to examine the digestive tract, "has the same problem".
NEXT STEPS
The EndoPil is still in its early stages of development.
The team has only tried the product on pigs, as well as one human volunteer.
Trials are expected to continue over the next two years as laid out in the National University of Singapore’s Institutional Review Board guidelines.
Ultimately, the team hopes to focus their efforts on making the product safe for use.
"Our next step is to try and show that people can swallow the capsule without an endoscope," said Prof Ho.
“Over the next two years, it’s all about engineering - to make sure that even if it fails, it will fail safely,” said Prof Phee.
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